The genes whose expression is associated with the regional distribution of GI in the human brain are available as supplementary materials from Goyal et al. The maps of average regional GI are available as supplementary materials from Vaishnavi et al. The NMT anatomical volume and associated probabilistic tissue segmentation maps (GM, WM and CSF) are freely available online: and. Region-wise maps of chimpanzee-to-human cortical expansion and HAR gene expression are available as supplementary materials from Wei et al. Cortical gene expression patterns were taken from the transcriptomic data of the AHBA ( ). The GTEx database (release V6p) is available at. The CoCoMac database on which it is based, is also available online at. The macaque connectome is available on Zenodo at. upon reasonable request for academic (noncommercial) purposes, subject to restrictions required to preserve participant confidentiality. The PET data that support the findings of this study are available from J.B.R. Macaque MRI data are available from the PRIME-DE through the Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC http:\fcon_/indi/indiPRIME.html). The HCP fMRI data are available online ( ). The HCP DWI data in SRC format are available online ( ). This information-resolved approach provides analytic tools to disentangle information integration from coupling, enabling richer, more accurate interpretations of functional connectivity, and illuminating how the human neurocognitive architecture navigates the trade-off between robustness and integration. Synaptic density mapping from positron emission tomography and convergent molecular and metabolic evidence demonstrate that synergistic interactions are supported by receptor diversity and human-accelerated genes underpinning synaptic function. The human brain leverages synergistic information to a greater extent than nonhuman primates, with high-synergy association cortices exhibiting the highest degree of evolutionary cortical expansion. Synergistic interactions instead support integrative processes and complex cognition across higher-order brain networks. Combining functional and structural neuroimaging with meta-analytic results, we demonstrate that redundant interactions are predominantly associated with structurally coupled, modular sensorimotor processing. How does the organization of neural information processing enable humansвЂ™ sophisticated cognition? Here we decompose functional interactions between brain regions into synergistic and redundant components, revealing their distinct information-processing roles.

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